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. 2008 Oct 24;3(10):e3524. doi: 10.1371/journal.pone.0003524

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Ratier et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Natural TcTS was not inhibited by VHHSI14. Comparison of VHH114 inhibition activity of the TcTS present in supernatants from Cl-Brener T. cruzi-infected cell cultures versus a recombinant TcTS611/2 enzyme. The decameric form of VHHSI14 was used. The values represent the average of two independent determinations. (B) Independent recombinant TcTSs are inhibited to different extents by VHHSI14. A fixed mass of 0.5 ng of different purified TcTSs from T. cruzi were preincubated with increasing concentrations of VHHSI14 decameric form and the remaining trans-sialidase activity was analyzed by TIA. The values represent the average of at least three independent determinations.