FIG. 2.
Effect of calcineurin inhibitors on morphology and rate of morphological hyphal tip progression through the M-Y transition stages during the M-Y transition of P. brasiliensis. (A to I) Morphology of the fungus during the M-Y transition at 24, 48, and 120 h at 37°C in the absence (Control; A to C) or presence of 2 μg/ml CsA (D to F) or FK506 (G to I). Arrows indicate hyphal tip enlargement (A), hyphal tip enlargement with buds or yeasts (B), or no hyphal tip enlargement (G). Scale bar = 10 μm. (J) Graphical summary of the rate of morphological changes during progression through the M-Y transition stages at 24, 48, 72, and 120 h at 37°C in the absence (CTR) or presence of calcineurin inhibitors (2 μg/ml CsA or FK506).