Figure 5. Effect of DNDS on swelling-activated D-[³H]aspartate release from cultured astrocytes and swelling-activated [³H]taurine uptake in cortical synaptosomes.

(a) Cultured astrocytes preloaded with D-[³H]aspartate were superfused with hypoosmotic medium in the presence or absence of 2 mM DNDS. The data are the mean values of five experiments for each group ±SEM. *** p<0.001 hypo, vs. DNDS. (b) Release of preloaded [³H]taurine from cortical synaptosomes was measured under isoosmotic (BASAL) and hypoosmotic (HYPO) conditions in the presence or absence of 2 mM DNDS. The data are the mean values of integral 10-min [³H]taurine release ±SEM of three experiments performed in quadruplicate. ***p<0.001 vs. isoosmotic control (BASAL), ^###p<0.001 vs. hypoosmotic control (HYPO).