Fig. 2.

Inhibition of U937 cell–plaque endothelium adhesion by antibodies to chemokines and their receptors. The assays were performed as described in Section 2: each graph shows adhesion in isotype matched control immunoglobulin 20 μg/ml compared to adhesion with antibody 20 μg/ml to the antigen indicated. The mean ± SE of U937 cell adhesion per length of endothelium in three quadruplicate experiments is shown. All antibodies cause highly significant inhibition of adhesion, ^∗∗∗p < 0.001. (A) Anti-MCP-1; (B) anti-GROα; (C) anti-IL-8; (D) anti-CCR-2; (E) anti-CXCR-2.