FIGURE 1.

A, sequence of the human P2X₇ 3′-UTR. Vertical lines within the sequence delineate subregions (segments) of the 3′-UTR that were subcloned into reporter plasmids to test RNA stability. Sequences in bold are putative target sites for miR-186 (end of Segment-2) and miR-150 (middle of Segment-3). Underlined are putative sites within the target that base pair with the seed sequence of the respective miRNAs. B, schema of the full-length human P2X₇ 3′-UTR with its division into Segments 1–3, and the putative target sites for miR-186 and miR-150.