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Zebrafish phenotypes after injection of capped PKD2 mRNA and/or pkd2 morpholino at the one-cell embryo stage
| Total embryos injected | Normal embryos | Cysts and body axis curvature | |
|---|---|---|---|
| A. Control MO | 303 | 303 (100%) | 0 (0%) |
| B. Human PKD2-L177 | 254 | 250 (98%) | 4 (2%) |
| C. Human PKD2-L223 | 252 | 20 (8%) | 232 (92%) |
| D. pkd2ATGMO | 222 | 12 (5%) | 210 (95%) |
| E. Human PKD2-D511V | 296 | 6 (5%) | 281 (95%) |
| F. pkd2ATGMO + human PKD2-D511V | 103 | 2 (2%) | 101 (98%) |
