TABLE 3.
Baseline and six-week lipid profile
| Patient subgroup | Baseline mean ± SD | Six-week mean ± SD | % Change mean ± SD | P* |
|---|---|---|---|---|
|
All patients (n=837) | ||||
| Low-density lipoprotein cholesterol, mmol/L | 3.43±0.85 | 2.38±0.87 | −30.05±18.40 | 0.001 |
| Total cholesterol, mmol/L | 5.55±1.00 | 4.36±1.01 | −20.84±14.06 | 0.001 |
| HDL-C, mmol/L | 1.22±0.31 | 1.21±0.30 | −0.08±13.20 | 0.856 |
| Triglycerides, mmol/L | 2.06±1.28 | 1.73±0.93 | −10.16±29.25 | 0.001 |
| Apolipoprotein B, g/L (n=506) | 1.17±0.41 | 0.92±0.27 | −19.84±18.13 | 0.001 |
| Total cholesterol/HDL-C ratio | 4.76±1.33 | 3.75±1.08 | −19.88±15.45 | 0.001 |
|
Diabetes, but no metabolic syndrome (n=114) | ||||
| Low-density lipoprotein cholesterol, mmol/L | 3.19±0.56 | 2.20±0.64 | −30.24±20.00 | 0.001 |
| Total cholesterol, mmol/L | 5.28±0.69 | 4.17±0.83 | −20.58±14.33 | 0.001 |
| HDL-C, mmol/L | 1.36±0.31 | 1.33±0.31 | −1.91±10.72 | 0.059 |
| Triglycerides, mmol/L | 1.65±0.82 | 1.44±0.64 | −6.78±30.31 | 0.019 |
| Apolipoprotein B, g/L (n=68) | 1.10±0.34 | 0.88±0.25 | −16.62±23.76 | 0.001 |
| Total cholesterol/HDL-C ratio | 4.04±0.86 | 3.24±0.69 | −18.61±14.42 | 0.001 |
|
Metabolic syndrome, but no diabetes (n=164) | ||||
| Low-density lipoprotein cholesterol, mmol/L | 3.62±1.01 | 2.59±1.00 | −27.71±18.95 | 0.001 |
| Total cholesterol, mmol/L | 5.79±1.12 | 4.64±1.18 | −19.42±15.87 | 0.001 |
| HDL-C, mmol/L | 1.07±0.25 | 1.08±0.22 | 2.00±14.37 | 0.076 |
| Triglycerides, mmol/L | 2.62±1.19 | 2.14±0.97 | −14.84±26.88 | 0.001 |
| Apolipoprotein B, g/L (n=102) | 1.32±0.72 | 0.99±0.32 | −20.32±17.81 | 0.001 |
| Total cholesterol/HDL-C ratio | 5.64±1.57 | 4.44±1.30 | −19.87±17.86 | 0.001 |
|
Metabolic syndrome and diabetes (n=244) | ||||
| Low-density lipoprotein cholesterol, mmol/L | 3.30±0.64 | 2.15±0.68 | −33.80±20.14 | 0.001 |
| Total cholesterol, mmol/L | 5.49±0.84 | 4.18±0.88 | −23.18±15.33 | 0.001 |
| HDL-C, mmol/L | 1.16±0.26 | 1.15±0.27 | −0.14±13.68 | 0.878 |
| Triglycerides, mmol/L | 2.27±1.01 | 1.93±1.00 | −12.18±29.68 | 0.001 |
| Apolipoprotein B, g/L (n=148) | 1.13±0.21 | 0.88±0.23 | −22.94±19.00 | 0.001 |
| Total cholesterol/HDL-C ratio | 4.89±1.08 | 3.76±0.98 | −22.06±16.96 | 0.001 |
|
Neither metabolic syndrome nor diabetes (n=315) | ||||
| Low-density lipoprotein cholesterol, mmol/L | 3.51±0.96 | 2.51±0.94 | −28.29±15.53 | 0.001 |
| Total cholesterol, mmol/L | 5.57±1.11 | 4.44±1.04 | −19.86±11.54 | 0.001 |
| HDL-C, mmol/L | 1.30±0.32 | 1.29±0.33 | −0.47±12.92 | 0.522 |
| Triglycerides, mmol/L | 1.74±1.49 | 1.47±0.81 | −7.38±29.39 | 0.001 |
| Apolipoprotein B, g/L (n=188) | 1.14±0.29 | 0.92±0.25 | −18.30±14.70 | 0.001 |
| Total cholesterol/HDL-C ratio | 4.47±1.25 | 3.58±0.96 | −18.64±12.89 | 0.001 |
*
P value based on Student’s t test for paired observations. HDL-C High-density lipoprotein cholesterol