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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Mol Cell Neurosci. 2008 May 11;38(4):518–525. doi: 10.1016/j.mcn.2008.04.013

Figure 4. Pan-caspase and JNK inhibitors delay death of OSNs.

Figure 4

(a) Survival of OSNs is extended when treated with pan-caspase inhibitors Boc-D-FMK (boc, 45 µM) and QVD-OPH (qvd, 3 µM) or JNK inhibitors, JNK Inhibitor VIII (j8, 5 µM) or SP600125 (sp, 5 µM) when compared to the control no treatment condition (nt). (b) Combinatorial treatments of each caspase inhibitor paired with each JNK inhibitor lead to further protection over either caspase or JNK inhibitor. Combinatorial effects were most significant by 96 hours in culture (* p<.05; **p<.01; ***p<.001; N=4).