Figure 7. Inhibition of JNK activity suppresses OSN death following OBX.
Olfactory epithelia from adult OMP-GFP mice were fixed 24 hours after unilateral OBX, and stained for both TUNEL reactivity and the presence of cleaved caspase-3. Both indicators of cellular death are present on the operated sides (OBX) of non-treated mice (NT). When mice were injected intraperitoneally with SP600125 (10 mg/kg) preceding OBX, both TUNEL and caspase-3 staining were absent indicating a delayed onset of death.