Table I.

The performance of CSS-Palm 2.0 was greatly improved by matrix mutation (MaM)

CSS-Palm 2.0	Threshold	Leave-one-out				New data set
		Ac (%)	Sn (%)	Sp (%)	MCC (%)	Ac (%)	Sn (%)	Sp (%)	MCC
Before MaMa	High	88.68	77.19	91.30	0.6495	89.00	56.60	93.82	0.5084
	Medium	82.38	82.89	82.26	0.5541	81.91	69.81	83.71	0.4256
	Low	69.43	87.83	65.22	0.4153	71.88	75.47	71.35	0.3303
After MaMb	High	89.60	77.19	92.43	0.6709	89.49	56.60	94.38	0.5227
	Medium	85.92	82.89	86.61	0.6142	86.31	73.58	88.20	0.5207
	Low	77.00	87.83	74.52	0.5024	76.28	81.13	75.56	0.4089

Both of the leave-one-out validation and the performance on the new data set were calculated and shown.

^aPerformance before MaM.

^bThe performance after MaM.