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. 2008 May 21;116(10):1294–1299. doi: 10.1289/ehp.11021

Figure 1.

Figure 1

(A) Schematic representation of the NO–cGMP relaxant pathway. Bold arrows indicate targets of the different drugs we used. (B) Wall tension recordings of the effect of ACh in PGF-precontracted rat intrapulmonary arteries incubated for 24 hr in the absence (black trace) or presence (gray trace) of SRM1648(200 μg/mL). Oscillations during contraction are not a characteristic feature of SRM1648-exposed arteries, because we also observed them in unexposed arteries.