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. 2008 May 21;116(10):1294–1299. doi: 10.1289/ehp.11021

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(A) Relaxant effect of ACh, SNP, DEA-NO, 8-Br-cGMP, or YC-1 in rat intrapulmonary arteries incubated for 24 hr in the absence (control) or presence of SRM1648 (at the indicated concentrations). Data are mean ± SE from 4–10 rats. (B) Levels of cGMP in rat intrapulmonary arteries incubated in the absence (white bar) or in the presence of SRM1648 (200 μg/ml for 24 hr, black bar) and subsequently exposed to ACh (10 μM). Data are mean ± SE from six rats. NS, not significant.

*p < 0.05; **p < 0.01.