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. 2008 May 21;116(10):1294–1299. doi: 10.1289/ehp.11021

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(A) Relaxant effect of ACh in rat intrapulmonary arteries incubated for 24 hr with SRM1648 (200 μg/mL), or with 1 mM tempol with or without SRM1648, or with 200 μM ascorbate with or without SRM1648, or with 1 mM tempol added 15 min before precontraction with PGF_2α, with or without SRM1648. Control arteries were incubated in medium only. Data are mean ± SE from four to six rats. NS, not significant. (B) DHE staining in rat intrapulmonary arteries incubated for 24 hr in the absence (control) or presence of 200 μg/mL SRM1648: representative photomicrographs of three independent experiments.