Figure 1.

Region of βc required for suppression of depletion-induced apoptosis. BA/F-wild, -544, -517, -Fall, -Δbox1, and -Δbox2 were cultured in hGM-CSF (10 ng/ml) or mIL-3 (1 ng/ml) containing medium or depleted medium for 24 h, and then DNA fragmentation (A) and caspase-3 like enzyme activity (B) were examined. In B, enzyme activities of factor-depleted sample (□), hGM-CSF supplied medium (▧) and mIL-3 supplied medium (█) are shown. Values are relative to those for the depleted sample. Experiments were repeated four times, and representative results of one experiment are presented.