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. 2008 Oct 24;3(10):e3525. doi: 10.1371/journal.pone.0003525

Figure 3. The predicted fraction of ancestral epitope precursors, MHC-binding peptides and CTL epitopes present in the HIV-1 clade B sequences declines over time.

Figure 3

The predicted fraction is plotted per sequence as a dot on the y-axis. Ancestral epitope precursors are defined by their C-terminal position (Fig. 1, 10th amino acid from the left) in the aligned sequences [3]. Similarly, MHC-binding peptides and CTL epitopes are defined by their C-terminal, but also by the MHC that they are predicted to bind to. *: significant decrease over time (Kendall Tau rank correlation test, p<0.01). The consensus sequence [65] is plotted as a square on the right-hand side of each panel.