Examination of G strand
length by DMS cleavage. (A) lane 1, G-cleavage pattern of mature
macronuclear DNA. Lanes 2-5, anlagen DNA isolated from cells treated
with 0, 10, 20, or 40 μg/ml aphidicolin. (B) lane 1, G-cleavage
pattern of mature macronuclear DNA; lane 2, anlagen DNA from untreated
cells; lane 3, anlagen DNA from fivefold concentrated cells; lane 4,
anlagen DNA from concentrated cells treated with 0.4% DMSO; lane 5,
anlagen DNA from concentrated cells treated with 40 μg/ml
aphidicolin. (C) Enlargement of lanes 4 and 5 from panel A showing the
G-cleavage pattern extending beyond G95–98. All anlagen
DNA was isolated at 60 h of development. The positions of the
guanines relative to the 3′ terminus are marked at the side of each
gel.