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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Cell Metab. 2008 Aug;8(2):132–145. doi: 10.1016/j.cmet.2008.07.001

Figure 2.

Figure 2

Analysis of the effects (mean ± SEM) of cPTH in MHC double KO mice, TCRβ −/− mice, nude mice adoptively transferred with either CD4+ or CD8+ cells, and WT mice treated with anti CD4/8 or irrelevant antibodies. * = p<0.05 as compared to the corresponding vehicle treated group. A Ex vivo µCT analysis of femur cortical bone, serum CTX and osteocalcin levels in class I and class II MHC double KO mice (n = 8 mice per group). B Ex vivo µCT analysis of femur cortical bone, serum CTX and osteocalcin levels in TCRβ −/− mice which lack αβ T cells (n = 8 mice per group). C Ex vivo µCT analysis of femur cortical bone, serum CTX and osteocalcin levels in nude mice adoptively transferred with either CD4+ or CD8+ cells (n = 10 mice per group). D Analysis of femur cortical bone by µCT, and serum CTX and osteocalcin levels in WT mice depleted of T cells in vivo by injection of anti CD4/8 mAbs. Controls were treated with irrelevant (Irr) mAbs (n = 9 mice per group). E Analysis of femur cortical and trabecular bone by histomorphometry in WT mice treated in vivo with anti CD4/8 or irrelevant antibodies (n = 9 mice per group).