Table II.
Comparison of patients (ovulatory infertility) treated with gonadotrophins and those treated with gonadotrophins plus letrozole in ovarian stimulation cycles for IUI.
| Data | Mitwally and Casper (2003) |
Healey et al. (2003) |
Bedaiwy et al. (2007) |
|||
|---|---|---|---|---|---|---|
| Letrozole + FSH | FSH | Letrozole + FSH | FSH | Letrozole + FSH | FSH | |
| Cycles, no. | 36 | 56 | 60 | 145 | 483 | 125 |
| Days of stimulation | 12.5 (1.9) | 11.4 (1.4) | 7.6 (2) | 9.5 (3) | 8.4 (1.7) | 7.7 (2.2) |
| FSH dose, IU | 465 (309) | 1114 (393)* | 600 (405) | 940 (464)* | 394 (355) | 1317 (943)* |
| Mature follicles on hCG day | 3 (1.2) | 2.7 (1.5) | 3.2 (1.2) | 2.2 (1.5) | 2.61 (1.3) | 3.45 (1.7) |
| Estradiol on hCG day, pmol/l | 1540 (877) | 3213 (1483)* | Not stated | Not stated | 1604 (1715) | 2585 (1792)* |
| Endometrial thickness on hCG day, mm | 9.1 (2) | 10 (2) | 8.5 (2.6)* | 9.4 (1.9) | 8.5 (2) | 9 (1) |
| Pregnancy rate, % | 22.2 | 21.4 | 21.6 | 20.9 | 19 | 16 |
| Multiple pregnancy rate, % | Not stated | Not stated | 0 | 5 | 22.5 | 31.2 |
Data as mean (SD) unless otherwise stated.
*P < 0.05 between the groups of letrozole + FSH and FSH alone.