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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Ultrasonics. 2008 Apr 14;48(4):279–296. doi: 10.1016/j.ultras.2008.04.004

FIGURE 8.

FIGURE 8

Electron micrographs showing transcellular and intracellular passage of horseradish peroxidase (HRP) after ultrasound-induced BBB disruption. This tracer appears black in the photomicrographs and has a molecular weight of 40 kDa. A: Intense vesicular transport is observed by numerous HRP-positive caveolae (example indicated by arrow) after sonication at 0.26 MHz in a rabbit brain. B: Passage of HRP through several interendothelial clefts (arrows) is observed after sonication at 1.5 MHz in a rat. The tracer has infiltrated the basement membrane and the interstitial space in the neuropil (*). (L: lumen; Ax: cross-sectioned axons; B: basement membrane). (Data from [201, 202]; Courtesy of N. Sheikov).