Table 1.
Hemodynamics
| Reperfusion (min) | ||||||
|---|---|---|---|---|---|---|
| Baseline | Intervention | Occlusion | 60 | 120 | 180 | |
| HR (min−1) | ||||||
| CON | 249 ± 40 | 241 ± 34 | 241 ± 34 | 237 ± 21 | 231 ± 25 | 220 ± 23 |
| He (1 Cycle) | 263 ± 29 | 254 ± 25 | 239 ± 18 | 230 ± 31* | 224 ± 31* | 220 ± 24* |
| He (3 Cycles) | 251 ± 33 | 243 ± 27 | 223 ± 18* | 216 ± 26* | 209 ± 22* | 199 ± 25* |
| He (5 Cycles) | 256 ± 28 | 245 ± 22 | 218 ± 20* | 217 ± 14* | 204 ± 9* | 194 ± 7* |
| SB21 (0.2 mg/kg) | 272 ± 24 | 265 ± 23 | 253 ± 23 | 243 ± 27* | 235 ± 24* | 229 ± 22* |
| SB21 (0.6 mg/kg) | 259 ± 31 | 252 ± 19 | 239 ± 17 | 227 ± 14* | 218 ± 22* | 209 ± 25* |
| He (1 Cycle) + SB21 (0.2 mg/kg) | 232 ± 10 | 224 ± 13 | 228 ± 23 | 222 ± 28 | 215 ± 29 | 207 ± 27 |
| He (1 Cycle) + SB21 (0.2 mg/kg) + ATR (5 mg/kg) | 273 ± 27 | 265 ± 21 | 257 ± 16 | 235 ± 31 | 234 ± 10* | 228 ± 8* |
| PIF (1.5 mg/kg) | 271 ± 29 | 257 ± 26 | 259 ± 26 | 251 ± 27* | 235 ± 26* | 215 ± 12* |
| PIF (3.0 mg/kg) | 275 ± 21 | 243 ± 22 | 243 ± 22 | 231 ± 30* | 224 ± 11* | 220 ± 12* |
| He (1 Cycle) + PIF (1.5 mg/kg) | 262 ± 19 | 238 ± 15 | 237 ± 22 | 238 ± 15 | 228 ± 17* | 215 ± 12* |
| He (1 Cycle) + PIF (1.5 mg/kg) + ATR (5 mg/kg) | 274 ± 24 | 267 ± 33 | 259 ± 36 | 249 ± 47 | 243 ± 47 | 246 ± 48 |
| MAP (mm Hg) | ||||||
| CON | 74 ± 7 | 68 ± 8 | 64 ± 8 | 63 ± 6 | 64 ± 6 | 64 ± 7 |
| He (1 Cycle) | 71 ± 7 | 75 ± 7 | 67 ± 9 | 67 ± 9 | 68 ± 12 | 68 ± 10 |
| He (3 Cycles) | 77 ± 8 | 82 ± 12 | 61 ± 11 | 60 ± 9* | 63 ± 9* | 60 ± 7* |
| He (5 Cycles) | 65 ± 11 | 65 ± 9 | 55 ± 9 | 57 ± 4 | 56 ± 6 | 58 ± 5 |
| SB21 (0.2 mg/kg) | 61 ± 7 | 63 ± 10 | 64 ± 5 | 57 ± 5 | 60 ± 7 | 61 ± 7 |
| SB21 (0.6 mg/kg) | 67 ± 11 | 70 ± 13 | 70 ± 12 | 64 ± 11 | 64 ± 10 | 63 ± 9 |
| He (1 Cycle) + SB21 (0.2 mg/kg) | 64 ± 8 | 68 ± 7 | 58 ± 8 | 58 ± 5 | 58 ± 7 | 58 ± 6 |
| He (1 Cycle) + SB21 (0.2 mg/kg) + ATR (5 mg/kg) | 69 ± 11 | 70 ± 13 | 60 ± 12 | 58 ± 10 | 59 ± 8 | 62 ± 12 |
| PIF (1.5 mg/kg) | 69 ± 7 | 74 ± 9 | 68 ± 11 | 60 ± 5 | 60 ± 8 | 63 ± 10 |
| PIF (3.0 mg/kg) | 64 ± 6 | 70 ± 12 | 54 ± 16 | 56 ± 9 | 58 ± 9 | 59 ± 11 |
| He (1 Cycle) + PIF (1.5 mg/kg) | 65 ± 9 | 73 ± 13 | 69 ± 12 | 59 ± 7 | 65 ± 10 | 60 ± 8 |
| He (1 Cycle) + PIF (1.5 mg/kg) + ATR (5 mg/kg) | 69 ± 12 | 71 ± 11 | 65 ± 8 | 64 ± 11 | 61 ± 9 | 61 ± 10 |
| RPP (min−1 · mm Hg · 10−3) | ||||||
| CON | 21.1 ± 4.3 | 19.2 ± 3.7 | 17.9 ± 3.2 | 18.0 ± 3.0 | 17.7 ± 2.5 | 16.4 ± 2.3* |
| He (1 Cycle) | 20.7 ± 1.4 | 21.2 ± 2.5 | 18.0 ± 2.8 | 17.6 ± 4.3 | 17.4 ± 4.6 | 16.7 ± 3.2* |
| He (3 Cycles) | 21.9 ± 4.2 | 22.7 ± 4.1 | 16.0 ± 3.8* | 15.3 ± 3.7* | 15.6 ± 2.6* | 14.1 ± 4.9* |
| He (5 Cycles) | 19.1 ± 3.3 | 18.1 ± 2.6 | 14.1 ± 2.4* | 14.4 ± 1.0* | 13.4 ± 1.3* | 13.1 ± 1.3* |
| SB21 (0.2 mg/kg) | 19.3 ± 2.7 | 19.5 ± 3.8 | 18.9 ± 2.7 | 16.2 ± 2.2 | 16.5 ± 2.5 | 16.2 ± 2.1* |
| SB21 (0.6 mg/kg) | 20.0 ± 3.8 | 22.7 ± 4.1 | 19.0 ± 3.5 | 16.7 ± 2.7 | 16.1 ± 3.3* | 15.3 ± 2.5* |
| He (1 Cycle) + SB21 (0.2 mg/kg) | 17.2 ± 2.2 | 17.6 ± 2.2 | 15.1 ± 2.4 | 15.1 ± 2.0 | 14.5 ± 2.6 | 13.9 ± 1.8* |
| He (1 Cycle) + SB21 (0.2 mg/kg) + ATR (5 mg/kg) | 22.5 ± 4.4 | 21.4 ± 5.1 | 17.9 ± 4.4 | 16.2 ± 3.7 | 16.2 ± 2.3* | 16.5 ± 3.1 |
| PIF (1.5 mg/kg) | 21.3 ± 2.8 | 21.4 ± 2.0 | 20.1 ± 3.2 | 17.8 ± 2.2* | 16.5 ± 1.5* | 17.0 ± 2.2* |
| PIF (3.0 mg/kg) | 20.6 ± 2.4 | 19.6 ± 3.8 | 15.3 ± 4.4* | 15.2 ± 3.5* | 15.4 ± 2.3* | 15.4 ± 2.6* |
| He (1 Cycle) + PIF (1.5 mg/kg) | 19.6 ± 2.8 | 19.7 ± 4.0 | 18.7 ± 3.0 | 16.6 ± 2.1 | 17.2 ± 3.1 | 15.3 ± 2.2* |
| He (1 Cycle) + PIF (1.5 mg/kg) + ATR (5 mg/kg) | 22.6 ± 4.4 | 22.7 ± 4.7 | 20.1 ± 4.0 | 19.2 ± 5.4 | 18.1 ± 5.0 | 17.6 ± 4.9 |
Data are mean ± sd.
HR = heart rate; MAP = mean arterial pressure; RPP = rate pressure product; CON = control; He = helium; SB21 = SB213763; PIF = pifithrin-α ; ATR = atractyloside.
*
Significantly (P ± 0.05) different from baseline.