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. 2008 Oct 15;22(20):2823–2830. doi: 10.1101/gad.1698108

Figure 2.

Figure 2.

The DPE is present in many genes that regulate the development of the Drosophila body plan. (A) Most of the Hox genes contain DPE-dependent core promoters. A schematic diagram of the Hox gene cluster is shown at the top. (lab) labial; (pb) proboscipedia; (Dfd) Deformed; (Scr) Sex combs reduced; (Antp P1) Antennapedia upstream promoter; (Antp P2) Antennapedia downstream promoter; (Ubx) Ultrabithorax; (abd-A) abdominal-A; (Abd-B) Abdominal-B. The wild-type (wt) and mutant DPE (mDPE) versions of the indicated core promoters (from −10 to +40 relative to the A + 1 start site) were subjected to in vitro transcription analysis with a Drosophila embryo nuclear extract. The resulting transcripts were detected by primer extension-reverse transcription analysis. (B) The core promoters of Caudal target genes contain functional DPE motifs. (ftz) fushi tarazu; (gt) giant; (h) hairy; (fkh) forkhead. In vitro transcription analysis was performed as in A.