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. Author manuscript; available in PMC: 2009 Jul 31.
Published in final edited form as: Pain. 2007 Dec 3;137(3):532–539. doi: 10.1016/j.pain.2007.10.016

Figure 4. Early behavioral signs of pain were attenuated by intrathecal pre-treatment with either K252a or TrkB/Fc.

Figure 4

Baseline weight distribution ratios were obtained for all animals before sciatic exposure (sham) or ligation, and then again 4h later. Note that vehicle-treated ligated animals (n=6) exhibited a decrease in their weight distribution ratio suggestive of pain behavior. On the other hand, pre-treatment with either K252a (n=6) or TrkB/Fc (n=4) 15 min before the ligation prevented this decrease suggesting complete relief from the pain behavior. Note further that injection of vehicle, K252a or TrkB/Fc did not modify the weight distribution ratios in sham-operated animals (n=4 for each treatment). Error bars represent the SEM. *p=0.001.