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. Author manuscript; available in PMC: 2008 Oct 17.
Published in final edited form as: Biochemistry. 2007 Mar 6;46(12):3724–3733. doi: 10.1021/bi062199j

Table 2.

Cleavage Site Specificity for MMP Hydrolysis of fTHP-4, fTHP-12, fTHP-13, and fTHP-14 at 30 °C.

Enzyme fTHP-4 fTHP-12 fTHP-13 C6-fTHP-14
MMP-1 Gly-Leu ND ND NC
MMP-2 Gly-Leu, Gly-Gln Gly-Met Asn-Phe NC
MMP-3 NC ND ND ND
MMP-8 Gly-Leu Gly-Met Asn-Phe Asn-Phe
MMP-9(Δ444–707) Gly-Leu Gly-Met ND NC
MMP-13 Gly-Leu Gly-Met Asn-Phe Asn-Phe
MT1-MMP(Δ279–523) Gly-Leu, Gly-Gln Gly-Met, Gly-Gln Gly-Gln Asn-Phe
MT2-MMP(Δ268–628) Gly-Leu Gly-Met, Gly-Gln Gly-Gln ND
MT5- MMP NC Gly-Met, Gly-Gln NC NC
MT6- MMP NC NC NC NC