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Activation Energies for Substrate Hydrolysis by MMPs.
| Enzyme | Substrate | Substrate | Ea |
|---|---|---|---|
| Tm (°C) | (kcal/mol) | ||
| MMP-8 | fTHP-4 | 36.3 | 12.8 ± 2.1 |
| MMP-8 | fTHP-13 | 39.0 | 15.5 ± 1.0 |
| MMP-13 | fTHP-4 | 36.3 | 17.4 ± 2.0 |
| MMP-13 | fTHP-13 | 39.0 | 12.7 ± 0.6 |
| MMP-1 | fTHP-4 | 36.3 | 20.0 ± 1.6a |
| MMP-1(Δ243–450) | fTHP-4 | 36.3 | 29.0 ± 0.6a |
| MMP-14(Δ279–523) | fTHP-4 | 36.3 | 8.8 ± 0.1a |
(5).
