Fig. 2.

Microbiota-mediated increase in adiposity is blunted in CONV-R Gpr41−/− mice. (A) Epididymal fat-pad weights (values from both fat pads were combined for each animal; n, 12 males per group). (B) Weight gain (n, 6 per group; followed one to two times per week for up to 4 weeks, between the ages of 5 and 9 weeks). (C) Adiposity in CONV-R WT and knockout mice, defined by DEXA (n, 9–13 males per group; 8–10 weeks old). (D and E) Fasting (4 h) serum leptin levels plotted against percentage total body fat (n, 5 per group). *, P < 0.05, **, P < 0.01 (Student's t test).