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. Author manuscript; available in PMC: 2009 Oct 15.
Published in final edited form as: J Cell Biochem. 2008 Oct 15;105(3):670–677. doi: 10.1002/jcb.21895

Figure 1.

Figure 1

Possible contributions of deregulated ribosomal biogenesis and translation to tumorigenesis. (A). Over-production of translational factors and ribosomal biogenesis components leads to cellular transformation. (B). Haploinsufficiency of ribosomal proteins and other factors involved in ribosomal biogenesis leads to clinical syndromes with increased susceptibility to cancer. Abbreviations: 5q-: 5q deletion syndrome; CHH: Cartilage-Hair hypoplasia; DBA: Diamond-Blackfan anemia; DC: dyskeratosis congenital; SDS: Shwachman-Diamond syndrome.