Table 1.

UGT1A1 and UGT1A9 allele and genotype frequencies

	African-Americans (n = 552)		Caucasians (n = 851)
	Cases (n = 227)	Controls (n = 325)	Cases (n = 310)	Controls (n = 541)
UGT1A1
−53	% (n)	% (n)	% (n)	% (n)
Alleles
5	0.06 (27)	0.08 (50)	0.001 (1)	0 (0)
6	0.48 (220)	0.49 (318)	0.68 (420)	0.68 (738)
7	0.40 (183)	0.39 (256)	0.32 (198)	0.32 (342)
8	0.05 (24)	0.04 (25)	0.002 (1)	0.002 (2)
9	0 (0)	0.001 (1)	0 (0)	0 (0)
Fisher exact test p		0.54		0.72
Genotypes
55	0 (0)	0.009 (3)	0 (0)	0 (0)
56	0.05 (11)	0.06 (19)	0.0032 (1)	0 (0)
57	0.05 (12)	0.06 (20)	0 (0)	0 (0)
58	0.02 (4)	0.02 (5)	0 (0)	0 (0)
66	0.25 (57)	0.24 (79)	0.4548 (141)	0.47 (252)
67	0.37 (84)	0.38 (125)	0.4387 (136)	0.43 (233)
68	0.05 (11)	0.05 (15)	0.0032 (1)	0.002 (1)
69	0 (0)	0.003 (1)	0 (0)	0 (0)
77	0.18 (40)	0.17 (54)	0.10 (31)	0.10 (54)
78	0.03 (7)	0.009 (3)	0 (0)	0.002 (1)
88	0.004 (1)	0.003 (1)	0 (0)	0 (0)
Fisher exact test P		0.73		0.85
Hwe P for controls		0.17		0.94
−3156
G	0.68 (309)	0.70(456)	0.72 (444)	0.71 (770)
A	0.32 (145)	0.30 (194)	0.28 (176)	0.29 (312)
χ2 test P		0.46		0.84
AA	0.10 (23)	0.10 (30)	0.08 (24)	0.08 (45)
AG	0.44 (99)	0.41 (134)	0.41 (128)	0.41 (222)
GG	0.46 (105)	0.50 (161)	0.51 (158)	0.51 (274)
χ2 test P		0.74		0.96
Hwe controls		0.77		0.91
−3279
T	0.21 (94)	0.18 (119)	0.50 (310)	0.55 (590)
G	0.79 (360)	0.82 (531)	0.50 (310)	0.45 (492)
χ2 test P		0.32		0.07
GG	0.64 (145)	0.66 (213)	0.23 (71)	0.21 (111)
GT	0.31 (70)	0.32 (105)	0.54 (168)	0.50 (270)
TT	0.05 (12)	0.02 (7)	0.23 (71)	0.30 (160)
χ2 test P		0.14		0.11
Hwe controls		0.14		0.73
UGT1A9
−275
T	0.82 (374)	0.823 (532)	0.91 (563)	0.93 (1002)
A	0.18 (80)	0.18 (118)	0.09 (57)	0.07 (80)
χ2 test P		0.82		0.19
AA	0.04 (6)	0.02 (8)	0.01 (3)	(0)
AT	0.30 (68)	0.31 (102)	0.16 (51)	0.15 (80)
TT	0.67 (153)	0.66 (215)	0.83 (256)	0.85 (461)
χ 2 or Fisher exact		0.931		0.062
test P
Hwe controls		0.30		0.05

For allele frequencies, N = total number of chromosomes, and for genotype frequencies, N=total number of individuals.

¹χ² test

²Fisher exact test