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. Author manuscript; available in PMC: 2008 Oct 20.
Published in final edited form as: Virology. 2007 Mar 21;364(1):73–86. doi: 10.1016/j.virol.2007.02.015

Figure 10. Immunohistochemical detection of other DNA repair proteins in cases of PML.

Figure 10

Bizarre astrocytes within demyelinated plaques of PML show cytoplasmic immunoreactivity for Artemis (Panel A). MRE11 was weakly detected in the cytoplasm of bizarre astrocytes from PML (Panel B). Immunohistochemistry for Nibrin (Panel C) showed that it was found in the cytoplasm of both bizarre astrocytes (arrowhead) and enlarged oligodendrocytes harboring inclusion bodies (arrow). Immunohistochemistry for Chk1 (Panel D) shows cytoplasmic reactivity in bizarre astrocytes (arrowhead) and in the nuclei of oligodendrocytes (arrows). All panels original magnification ×400 except Panel B ×200. Immunolabeling for MRE11, Nibrin or Chk1 was not observed in areas outside of the PML lesions or in brain samples from the control patients without PML (data not shown).