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Keloid fibroblasts (K-C3 and K-Ea) respond to PAI-1 siRNA with decreased PAI-1 and collagen accumulation. Culture, treatment, and data handling were as in Figure 5A. □, PAI-1 expression.
, Collagen accumulation. A: Keloid strain K-C3. B: Keloid strain K-Ea. PAI-1 siRNAs: siRNA5, siRNA6, or siRNA7; siRNA Mixture: a mixture of siRNA5, siRNA6, and siRNA7 (a total of 100 nmol/L). *P ≤ 0.05; **P≤ 0.01; #P ∼ 0.1.
