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Expression of Noggin and BMP signaling in nipples of 6- to 8-month-old WT, Noggin-overexpressing, and Msx2−/− mice. a: Nipples were harvested from WT and transgenic mice and analyzed for levels of endogenous Noggin, ectopic levels of KRT14-Noggin, Bmpr1a, and control L32 genes by RT-PCR. b: A Noggin-lacZ mouse was used to locate Noggin expression and further confirmed by in situ hybridization for Noggin on a control nipple.
