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CGI-58 Immunolabeling in Harlequin Ichthyosis Patients’ Epidermis. In skin specimens from the two harlequin ichthyosis patients with defective LGs (A, B), extremely reduced CGI-58 expression was seen compared with strong CGI-58 staining in normal human skin (C). CGI-58, green (FITC); nuclear stain, red (propidium iodide). White arrows, the granular layer. Scale bars = 50 μm.
