Figure 5.

Reduced barrier function of Hai-1/Spint1-deficient epidermis. Newborn mice were obtained by caesarian section at E18.5, resuscitated, separated from their mother to prevent fluid intake, and placed in a 37°C incubator. The rate of epidermal fluid loss was calculated by measuring the reduction of body weight. The values are means ± SD. The time course difference between two groups was statistically significant (P < 0.005, repeated measure analysis of variance).