TABLE 2.
Rat models of pneumonia
| Route of infection | Rat strain | Pneumococcal serotype(s) | Aim(s) of study | Readouts | Utility | Reference(s) |
|---|---|---|---|---|---|---|
| i.t. | R strain albino | 3 | Antimicrobial therapy, model description | CFU, histology | Pathogenesis of lobar pneumonia, drug efficacy studies | 14 |
| i.t. | Sprague-Dawley | 3 | Model in cirrhotic and chronically intoxicated rats | Survival, CFU, hematology and chemistry tests | Pneumonia in alcoholic and cirrhotic patients | 71, 166 |
| Intrabronchial | Wistar | 3 | Effect of pneumolysin on lungs | Lung histology | Pathogenesis of lobar pneumonia, detailed surgery information | 79 |
| Intrabronchial | Infant CD | 6 | Model of penicillin-resistant pneumonia in neutropenic rats | Gross pathology and CFU | Drug efficacy studies | 221 |
| Intrapulmonary | CD | 2, 6B | Model of penicillin-resistant pneumonia in neutropenic rats | CFU, lung histology, pharmacokinetics | Antibiotic efficacy studies | 49 |
| Intrapulmonary | Infant Sprague-Dawley | 1, 3, 4, 5, 6B, 7F, 9V, 14, 19F, 23F | Low-dose pneumonia model | Survival, CFU, lung histology | Pathogenesis of pneumonia in children, vaccine studies | 214 |