TABLE 4.
Mouse models of sepsis
| Route of infection | Mouse strain(s) | Pneumococcal serotype | Aim(s) of study | Readouts | Utility | Reference |
|---|---|---|---|---|---|---|
| i.v. | CBA/N, DBA/2, BALB/c | 3 | Protection by anti-PCa antibodies, model description | Survival, CFU | Bacterial clearance mechanisms, passive and active protection | 43 |
| i.v. | CD-1 | 3 | Host response to sepsis | CFU, hematological parameters, cytokines, histology | Pathogenesis of sepsis | 251 |
| i.p. | CBA/N, BALB/c | 3 | Protection by anti-PC antibodies, model description | Survival, CFU | Passive and active protection, drug efficacy and virulence studies | 43 |
a
Anti-PC, anti-phosphocholine.