TABLE 6.
Mouse models of meningitis
| Route of infection | Mouse strain(s) | Pneumococcal serotype(s) | Aim of study | Readouts | Utility | Reference |
|---|---|---|---|---|---|---|
| Intracerebral (ventricular) | CD-1 | NSa | Drug efficacy | CFU in brain and organs | Therapeutic studies | 220 |
| Intracerebral (right forebrain) | C57BL/6 | 3 | Model description | Immunohistochemistry, CFU, clinical scores, behavioral tests | Meningitis pathophysiology, drug and virulence studies | 86 |
| i.cist. (cisterna magna) | C57BL/6 | 3 | Role of eNOSb | Survival, clinical scores, cytokines, and histology | Meningitis pathophysiology, hearing loss, therapeutic studies | 136 |
| Intracerebral (subarachnoidal) | MF1 | 2, 3, 4 | Model description | Histology, survival, CFU | Virulence studies, host-parasite interaction | 59 |
| i.cist. (cisterna magna) | Infant BALB/c C57BL/6, CD-1 | 3 | Model of brain damage | Survival, CFU in CSF, histology, and apoptosis | Meningitis in children, brain damage | 95 |
| i.p. | Infant C57/129 | 6 | Role of ICAM-1 | Survival, CFU in organs, cytokines | Hematogenous meningitis, drug studies | 230 |
| i.n. | Swiss | 6 | Model description | Brain histology, CFU in CSF, cytokines | Pathogenesis via natural infection, drug studies | 268 |
| i.n. | Swiss | 2 | Model description | CFU in brain and other organs | Disease pathogenesis via natural infection | 160 |
a
NS, not specified.
b
eNOS, endothelial nitric oxide synthase.