Table 4.

Schedule of the tumour cell reproductive activities following 10 Gy insult

Days after irradiation	HeLa	Namalwa
1	Bridged mitoses/reunion of sister nuclei/cells	Arrest in G2
2	Bi-nucleation, bipolar mitoses of their subnuclei forming MNGC (about 70%); metaphase arrests of mono- nucleated cells	Aberrant mitoses, many of them are bridged.
3	Bi-polar mitoses of subnuclei in bi-and MNGC. A new, smaller wave of bi- nucleation.	Metaphase arrests, emergence of MONGC (about 80%) and MNGC (about 20%)
4–5	Metaphase arrests of most polyploidy mitoses, increase of polyploidy to 32 C; bi-polar mitoses of subnuclei in MNGC; A new smaller wave of multinucleation*	Metaphase arrests ofpolyploidy mitoses, incr ease of polyploidy to 32C; bi-polar mitoses of subnuclei in MNGC
5–6	Major cessation of further polyploidisation, apoptotic crisis, true endomitosis, bi- and multi-polar cell divisions processing anaphase in surviving cells	Major cessation of further polyploidisation, apoptotic crisis, true endomitosis, bi-and multi-polar cell divisions processing anaphase in surviving cells
7–9	Beginning of clonogenic regrowth of small para-diploid cells; cessation of proliferative activities and appearance of senescence markers in the majority of giant cells; continuation of mitotic attempts in the minor fraction of giant cells.	Beginning of clonogenic regrowth of small para-diploid cells; cessation of proliferative activities and appearance of senescence markers in the majority of giant cells; continuation of mitotic attempts in the minor fraction of giant cells.

^*The second and possibly next waves of polyploidisation were noticed also in later terms