Table III.
PRCC and eFAST results on the 2-compartmental ODE model. This table summarizes results shown in great detail in Supplement E online, where different sample sizes are used for both LHS/PRCC and eFAST. The time points tested are [100 500 1000]. The sign of PRCC is shown in parenthesis. The top two or three parameters are highlighted. The order they are listed reflect the magnitude of the coefficient (in absolute value, going from high to low). [(*): significant; i.e., p<0.01]. Panel A: PRCC and eFAST results grouped by significance over time. Bacterial load is the output of interest. Panel B: Inter and Intra-compartmental effects. PRCC and eFAST results for BE at time 1000. Panel C: Inter and Intra-compartmental effects. PRCC and eFAST results for MDC at time 500. Panel D: Inter and Intra-compartmental effects. PRCC and eFAST results for Th1 at time 100.
| Sensitivity index | Parameter with a significant sensitivity index | ||
|---|---|---|---|
| Day 100 | Day 500 | Day 1000 | |
| PRCC | sIDC(-), δ10, k2(-),k4(-), δ6 (-), k14(-) | k2(-), sIDC (-), k4, k3, k14(-), δ10, δ8, ξ(-) | k2 (-), δ10, k3, k4, sIDC(-), ξ(-), k14(-) |
| eFAST - Si(*) | k2 | k14, ξ, k2, k3, sIDC | k3, k14, k2, sIDC, ξ |
| eFAST - STi(**) | k2 | k14, ξ, k2, k3, sIDC, k4 | k3, k14, k2, sIDC, ξ, k4 |
| Panel A: US analysis for extracellular bacterial load (BE) over three time points | |||
| Sensitivity index | Parameter with a significant sensitivity index | ||
| Inter-compartment | Intra-compartment | ||
|
| |||
| PRCC | δ10, ξ(-) | k2(-), k3, k4, sIDC(-), k14(-) | |
| eFAST - Si(*) | ξ | k3, k14, k2, sIDC | |
| eFAST - STi(**) | ξ | k3, k14, k2, sIDC, k4 | |
| Panel B: US analysis for extracellular bacterial load (BE) at time 1000 days post infection | |||
| Sensitivity index | Parameter with a significant sensitivity index | ||
| Inter-compartment | Intra-compartment | ||
|
| |||
| PRCC | sIDC, k2, k3(-), δ9 (-) | δ10 | |
| eFAST - Si(*) | k14, k4, k3, sIDC | ξ | |
| eFAST - STi(**) | k14, k4, k3, sIDC, k2 | ξ | |
| Panel C: US analysis for mature dendritic cells (MDC) at time 500 days post infection | |||
| Sensitivity index | Parameter with a significant sensitivity index | ||
| Inter-compartment | Intra-compartment | ||
|
| |||
| PRCC | ξ, δ10 | k3, k2, sIDC, δ4, k14(-) | |
| eFAST - Si(*) | δ10 | k2, sIDC | |
| eFAST - STi(**) | δ10 | k2, sIDC, δ8 | |
| Panel D: US analysis for T Helper cells type I (Th1) at time 100 days post infection | |||