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Chemical modification of phosphoserine residues using β-elimination (reaction 1) and nucleophilic addition with 2-amino-ethanethiol (reaction 2) in order to produce a protease-cleavable S-2-aminoethylcysteine (Aec) lysine analogue. The Aec derivative is recognized by the proteases trypsin or Lys-C, and facilitates cleavage of the peptide bond that is C-terminal to the Aec residue (reaction 3).
