Functional distribution of COGs among replicons in the JS666 genome sequence. COG designations: J, translation and ribosomal structure/biogenesis; K, transcription; L, DNA replication, recombination, and repair; C, energy production/conversion; E, amino acid transport/metabolism; G, carbohydrate transport/metabolism; H, coenzyme metabolism; I, lipid metabolism; P, inorganic-ion transport/metabolism; Q, secondary metabolism; M, cell envelope biogenesis outer membrane; N, cell motility and secretion; O, posttranslational modification and protein turnover; T, signal transduction mechanisms; U, intracellular trafficking and secretion; R, general function prediction only; and S, function unknown.