TABLE 1.
Endotoxin measurements by the LAL testa
| Solution | Filtration time (h) | Amt (EU/ml) of endotoxins in (charged) filter A sample:
|
Amt (EU/ml) of endotoxins in (charged) filter B sample:
|
Amt (EU/ml) of endotoxins in (noncharged) filter C sample:
|
Amt (EU/ml) of endotoxins in (noncharged) filter D sample:
|
||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | ||
| CS | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | 1 | 0.5 | 1 | 1 | 1 | 1 | 1 | 1 | |
| 24 | 1 | 0.5 | 1 | 1 | 0.5 | 1 | 1 | 1 | |
| 48 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| 72 | 1 | 1 | 1 | 0.5 | 1 | 1 | 1 | 1 | |
| 96 | 1 | 1 | 1 | 1 | 0.5 | 1 | 1 | 1 | |
| FF | 0 | <0.03 | <0.03 | <0.03 | <0.03 | <0.03 | <0.03 | 0.125 | 0.03 |
| 8 | <0.03 | <0.03 | <0.03 | <0.03 | 0.5 | 1 | 0.25 | 0.5 | |
| 24 | <0.03 | <0.03 | <0.03 | <0.03 | 1 | 0.5 | 1 | 1 | |
| 48 | <0.03 | <0.03 | <0.03 | <0.03 | 2 | 8 | 1 | 1 | |
| 72 | 0.03 | <0.03 | <0.03 | <0.03 | 0.5 | 0.5 | 2 | 1 | |
| 96 | <0.03 | <0.03 | <0.03 | <0.03 | 0.5 | 2 | 1 | 1 | |
| Conclusionb | R | R | R | R | NR | NR | NR | NR | |
a
Results for 2 samples representative of the 20 samples analyzed per filter are shown. Filters A and C were obtained from GVS, and filters B and D were obtained from Pall.
b
R, the filter retained endotoxins; NR, the filter did not retain endotoxins.