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. Author manuscript; available in PMC: 2008 Oct 20.
Published in final edited form as: J Neurosci Res. 2005 Jan 1;79(1-2):240–247. doi: 10.1002/jnr.20293

Fig. 1.

Fig. 1

Partial reactions of the PDHC. The PDHC catalyzes the oxidative decarboxylation of pyruvate to form acetyl CoA. The enzyme complex is composed of three major subunits: pyruvate dehydrogenase (E1), dihydrolipoyl transacetylase (E2), and dihydrolipoyl dehydrogenase (E3). In addition to pyruvate and coenzyme A (CoASH), PDHC also requires a host of cofactors, including thiamine pyrophosphate (TPP), nicotinamide adenine dinucleotide (NAD+), flavin adenine dinucleotide (FAD), and lipoic acid (LIP).

HHS Vulnerability Disclosure