Fig. 4.

Effects of cardiac arrest and resuscitation on canine frontal cortex PDHC immunoreactivity. Canine frontal cortex neuronal PDHC immunoreactivity remains unchanged after 10-min cardiac arrest (A, B). Confocal fluorescent imaging, using a polyclonal antibody to the entire PDHC complex, reveals diminished immunoreactivity after 2-hr reperfusion (C), which remains low at 24 hr reperfusion (D). Reprinted from Experimental Neurology, Vol 161, Bogaert et al., Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resuscitation, p 115-126, ^©2000 with permission from Elsevier.