Table 3.

VH5 Mutable Sites Information

Site	Total mutations at Site	Stem stability (−ΔG) a	All occurrences of each Site in a patch	No. S-IB repeats exposing all Sites b
S1	174	13.9 (5′)	12	7
S2	9	13.9 (3′)	6	4
S3	228	3.7 (5′)	6	5
S4	219	3.7 (3′)	5	3
S5	265	4.7 (5′)	5	4
S6	286	4.7 (3′)	3	1

^aThe 5′ side of each stem precedes the loop Sites and the 3′ side precedes Sites 2, 4, and 6.

^bSee Figure 3B.