FIG. 4.
Regeneration of β-cell mass, but not gross pancreatic tissue, was impaired in FoxM1Δpanc mice. A: Wet weight of the pancreatic splenic lobe was measured immediately following (day 0) or 7 days after PPx or sham. The majority of tissue was removed by PPx, and a moderate amount of regeneration occurred within 7 days in both control (□) and FoxM1Δpanc (▪) mice. B: β-Cell mass, which takes into account tissue wet weight, was significantly reduced within the splenic lobe of FoxM1Δpanc pancreata after a sham operation, and regeneration of β-cell mass was not observed in FoxM1Δpanc mice following PPx. C: β-Cell mass within the duodenal lobe of FoxM1Δpanc pancreata was only significantly reduced in comparison with control pancreata following PPx. Error bars represent SE. Two-way ANOVA with Bonferroni's posttests, comparing sham day 7 versus PPx day 0 and PPx day 0 versus PPx day 7, was used to measure significance. n = 4–6 per group. ns, not significant.