TABLE 1.
Morphometric data of myelinated fibers in sural nerves
| Limb | Fascicle area (μm2) | Fiber number | Fiber area (μm2) | Density (fiber/mm2) | Occupancy rate (%) | Myelin area (μm2) | Axon area (μm2) | Axonal-to-myelin area ratio | Axonal diameter (μm) | Myelin thickness (μm) | Axonal circularity |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal–saline-injected limb | 56,852 ± 4,560 | 701 ± 54 | 37.1 ± 2.7 | 11,876 ± 1,585 | 45.5 ± 5.8 | 22.7 ± 1.5 | 15.2 ± 1.2 | 0.68 ± 0.08 | 4.34 ± 0.19 | 2.52 ± 0.20 | 0.794 ± 0.008 |
| Normal–MSC-transplanted limb | 54,896 ± 5,869 | 730 ± 29 | 38.5 ± 4.6 | 13,206 ± 1,796 | 49.3 ± 2.6 | 23.2 ± 2.7 | 15.1 ± 0.9 | 0.66 ± 0.09 | 4.33 ± 0.10 | 2.66 ± 0.20 | 0.796 ± 0.009 |
| Diabetic–saline-injected limb | 48,231 ± 4,686 | 668 ± 87 | 34.9 ± 3.3 | 14,459 ± 1,179 | 49.5 ± 4.8 | 19.8 ± 3.1 | 15.5 ± 1.0 | 0.76 ± 0.12 | 4.44 ± 0.14 | 2.33 ± 0.29 | 0.771 ± 0.011* |
| Diabetic–MSC-transplanted limb | 51,895 ± 5,768 | 745 ± 33 | 37.2 ± 2.8 | 14,471 ± 1,444 | 52.7 ± 4.0 | 20.9 ± 2.0 | 15.7 ± 1.4 | 0.79 ± 0.11 | 4.47 ± 0.21 | 2.41 ± 0.25 | 0.796 ± 0.009† |
Data are means ± SD.
*
P < 0.01 vs. normal rats;
†
P < 0.001 vs. diabetic-saline rat.