FIG. 1.

In silico and genotype fine-mapping of the GCKR locus. To define the strongest signal for the association on chromosome 2p23 for triglycerides, a region spanning ∼417 kb and containing 17 annotated genes was fine-mapped by two different approaches, imputation of untyped SNPs (29) (or so-called in silico fine-mapping) (A) and genotyping tagging SNPs across the region (B). Both in silico and genotype fine-mapping methods indicated the Pro446Leu as the variant with the strongest association with triglyceride levels. The genotype consensus rate between the imputed genotypes and genotyped genotypes was ∼95.7%.