TABLE 2.
Triglyceride concentrations according to genotype at GCKR rs780094* in 12 studies comprising 46,549 individuals
| Country | Study | CC (mg/dl) | CT (mg/dl) | TT (mg/dl) | Minor allele frequency | Z score | P value |
|---|---|---|---|---|---|---|---|
| Finland and Sweden | DGI* | 136 ± 89 (1,142) | 144 ± 103 (1,194) | 164 ± 114 (300) | 0.34 | −5.76 | 3.7 × 10−8 |
| Sweden | MDC-CC* | 117 ± 70 (2,207) | 123 ± 71 (2,457) | 128 ± 74 (639) | 0.35 | −5.45 | 1.7 × 10−7 |
| Sweden | MPP | 107 ± 70 (4,059) | 113 ± 77 (4,616) | 117 ± 72 (1,425) | 0.37 | −6.17 | 1.3 × 10−9 |
| Sweden | NORDIL | 151 ± 78 (2,223) | 157 ± 79 (2,220) | 172 ± 87 (572) | 0.34 | −6.14 | 7.4 × 10−9 |
| Sweden | Skania Diabetes 2000 Registry | 205 ± 148 (1,076) | 224 ± 97 (1,069) | 253 ± 104 (259) | 0.33 | −4.87 | 1.8 × 10−6 |
| Finland | Botnia-PPP | 106 ± 58 (1,273) | 115 ± 69 (1,429) | 125 ± 69 (409) | 0.36 | −5.62 | 4.8 × 10−8 |
| Finland | FINRISK | 128 ± 86 (3,009) | 130 ± 89 (3,398) | 142 ± 105 (931) | 0.36 | −5.00 | 8.0 × 10−7 |
| Spain | Valencia | 108 ± 66 (446) | 112 ± 64 (792) | 118 ± 71 (370) | 0.48 | −2.26 | 0.02 |
| U.S. | Dallas Heart Study blacks | 103 ± 90 (1,163) | 108 ± 78 (444) | 110 ± 59 (44) | 0.16 | −2.53 | 0.01 |
| U.S. | Dallas Heart Study Hispanics | 149 ± 138 (244) | 151 ± 124 (263) | 161 ± 155 (58) | 0.34 | −0.56 | 0.29 |
| U.S. | Dallas Heart Study whites | 131 ± 115 (342) | 135 ± 97 (455) | 164 ± 124 (145) | 0.40 | −4.04 | 4.4 × 10−5 |
| U.S. | GOLDN | 109 ± 75 (378) | 143 ± 90 (538) | 133 ± 87 (146) | 0.39 | −2.24 | 0.03 |
| U.S. | BPRHS | 153 ± 104 (423) | 165 ± 92 (330) | 174 ± 118 (84) | 0.30 | −2.96 | 0.003 |
| Singapore | Singapore NHS-98 Chinese | 112 ± 64 (842) | 120 ± 71 (1233) | 131 ± 82 (616) | 0.46 | −5.41 | 3.0 × 10−5 |
| Singapore | Singapore NHS-98 Malays | 132 ± 75 (268) | 150 ± 91 (332) | 153 ± 97 (134) | 0.41 | 0.02 | |
| Singapore | Singapore NHS-98 Asian Indians | 140 ± 79 (332) | 151 ± 89 (188) | 163 ± 109 (28) | 0.22 | 0.08 | |
| Total n = 46,549 | 19,427 | 20,958 | 6,164 | Meta-analysis P value 3 × 10−56 | |||
Data means ± SD (n) (continuous raw measures). Association analyses were conducted with an outcome variable of residual log- triglyceride concentration after adjustment for age, sex, and diabetes status. For ease of interpretation, unadjusted triglyceride concentrations are presented in the table. To convert the values to millimoles per liter, multiply triglycerides by 0.01129. All P values are two sided.
*
DGI and MDC-CC results have been reported in ref. 1. BPRHS, Boston Puerto Rican Health Study.