Table 2.
Characteristics at Time of Disease Recurrence
| Number of patients | Percent | |
|---|---|---|
| Year of recurrence | ||
| 1990–1995 | 22 | 17% |
| 1996–2001 | 64 | 50% |
| 2002–2007 | 43 | 33% |
| Site of recurrence* | ||
| Lung | 82 | 64% |
| Bone | 21 | 16% |
| Lymph node-regional | 14 | 11% |
| Liver | 13 | 10% |
| Local recurrence | 13 | 10% |
| Brain | 8 | 6% |
| Lymph node – distant | 5 | 4% |
| Other# | 14 | 11% |
| Karnofsky performance status | ||
| ≤60% | 8 | 6% |
| 70% | 15 | 12% |
| 80% | 33 | 25% |
| 90% | 46 | 36% |
| 100% | 27 | 21% |
| LDH > 1.5x upper limit of normal | ||
| Yes | 8 | 6% |
| No | 121 | 94% |
| Corrected calcium > 10 mg/dl | ||
| Yes | 22 | 17% |
| No | 107 | 83% |
| Hemoglobin (female<11.5 g/dl, male<13.0 g/dl) | ||
| Yes | 43 | 33% |
| No | 66 | 67% |
| Time to recurrence < 12 months | ||
| Yes | 57 | 44% |
| No | 72 | 56% |
*
Includes patients with more than one site of recurrence
#
Includes pancreas (5), contralateral adrenal gland (4), thyroid (2) and one each for vaginal, spleen, and ethmoid