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. 2008 Sep 30;99(8):1322–1329. doi: 10.1038/sj.bjc.6604688

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Copyright © 2008 Cancer Research UK

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Summary of the mechanism of NET1-mediated tumour migration and invasion. In this study lysophosphatidic acid (LPA) was shown to drive the expression of NET1, which increased the activation of RhoA (a process that was inhibited by C3 exoenzyme). Knockdown of NET1 was shown to reduce the levels of active RhoA and also a loss in the organisation of the cytoskeletal architecture. Knockdown of NET1 furthermore resulted in a decrease in the levels of tumuor cell migration and invasion.