Table 3. Multivariate analyses (Cox regression) of various prognostic parameters in the total cohort and subgroup of patients with curative intent.

				Overall survival
				P-value	RR	95% CI
(a) Total group of patients (n=197)
T stage				0.81	1.0	0.7–1.4
Nodal status				0.94	0.9	0.5–1.6
Distant metastasis				0.71	0.7	0.1–5.2
Surgical margin				0.02	1.9	1.1–3.5
TROP2 overexpression				0.01	1.8	1.1–3.1

	Progression-free survival			Overall survival
	P-value	RR	95% CI	P-value	RR	95% CI
(b) Subgroup of patients treated surgically with curative intent (n=134)
T stage	0.720	0.9	0.6–1.3	0.721	0.9	0.6–1.3
Nodal status	0.545	1.1	0.6–2.1	0.764	0.9	0.5–1.5
Surgical margin	0.276	1.4	0.7–2.7	0.012	2.0	1.1–3.5
TROP2 overexpression	0.070	1.6	0.9–2.8	0.009	1.8	1.1–3.0
Nodal status	0.562	1.1	0.6–2.1	0.772	0.9	0.5–1.5
Surgical margin	0.301	1.3	0.7–2.6	0.012	1.9	1.1–3.3
TROP2 overexpression	0.073	1.6	0.9–2.7	0.009	1.8	1.1–3.0
Surgical margin	0.185	1.4	0.8–2.7	0.009	1.9	1.1–3.1
TROP2 overexpression	0.053	1.6	0.9–2.8	0.009	1.8	1.1–2.9
Nodal status	0.193	1.3	0.8–2.2	0.288	1.2	0.8–1.9
TROP2 overexpression	0.014	1.8	1.1–2.9	0.000	2.0	1.3–3.1

Abbreviations: CI=confidence Interval; RR=relative risk.